Senior Scientist, Investigative ADMET Laboratory

Company: Eli Lilly and Company
Location: Louisville
Posted on: February 7, 2026

Job Description:

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. Position Summary: The Investigative ADME, Toxicology and Bio-Analytical Research team focuses on drug discovery using innovative scientific approaches. We seek an experienced lab scientist to support and help develop our cross-site Investigative ADMET Laboratory capabilities, including playing a substantive role to design, build and deploy automation-friendly screening infrastructure. The candidate should have a passion and consistent track record for developing capacity enabling screening, mechanistic, investigative assays which deliver reliable results at the pace discovery research demands. Strong collaboration with ADMET Project Leaders, lab-based scientists and medicinal chemists is essential. This role requires excellent people and communication skills, a positive attitude, willingness and agility to learn, attention to detail, and the ability to thrive in a fast-paced team environment. The successful candidate will also be eager to apply emerging techniques in AI, agentic agents and automation to their laboratory work and results. Responsibilities: Maintain Safety in the workplace as a primary priority Design, implement, and interpret in vitro ADME assays (metabolic stability, protein binding, reaction phenotyping, CYP inhibition/induction, transporter studies) Develop and validate novel assays to predict in vivo outcomes and address DDI assessments Generate data for PBPK modeling and collaborate with medicinal chemistry Operate LC-MS/MS instrumentation (Sciex/Shimatzu platforms) for quantitative/qualitative analysis Partner with CROs to design studies and interpret outsourced data Present findings, author technical reports Minimum Qualifications BS with 8 years similar experience) within the pharmaceutical sector or related field. Experience in vitro ADME assay design, execution, and interpretation Experience with LC-MS/MS platforms and data analysis software (i.e. Sciex and Shimatzu platforms, Analyst software) Additional Preferences: MS with 5 years academic/research/industry experienceProven track record of delivering high-quality data in fast-paced, deadline-driven environments Strong communication skills and ability to work effectively in cross-functional teams Familiarity with CYP induction, transporter studies, and mammalian cell culture Understanding of ICH guidelines and regulatory ADME requirements Adaptive and applies creative problem solving to meet emerging needs Knowledge of IVIVE and PBPK modeling applications Self-driven and data-dependent decision maker Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups. Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $72,000 - $213,400 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. WeAreLilly

Keywords: Eli Lilly and Company, Broomfield , Senior Scientist, Investigative ADMET Laboratory, Science, Research & Development , Louisville, Colorado